Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Q: Multiple genes mutations is usually necessary to develop cancer.

A: What is usually necessary to develop cancer?
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Q: Circannual behavioral rhythms are linked to the yearly cycle of seasons.

A: What type of behavioral rhythms are linked to the yearly cycle of seasons?
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Q: Sex-linked traits are located on genes on sex chromosomes.

A:
Sex-linked traits are located on genes on what chromosomes?
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