Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Input: Consider Input: Pleiotropic effects causes symptoms associated with sickle-cell disease.

Output: What causes symptoms associated with sickle-cell disease?


Input: Consider Input: Based on the passage, they may represent individual people is one conclusion archaeologists have reached about the statues.

Output: Based on the passage, what is one conclusion archaeologists have reached about the statues?


Input: Consider Input: Arterial blood pressure is highest when the heart contracts during ventricular systole.
Output: Which blood pressure is highest when the heart contracts during ventricular systole?