Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Example Input: Pleiotropic effects causes symptoms associated with sickle-cell disease.
Example Output: What causes symptoms associated with sickle-cell disease?

Example Input: When the energy of the earthquake reaches shore, it forms a huge wave called a tsunami.
Example Output: When the energy of the earthquake reaches shore, it forms a huge wave called?

Example Input: Ph food enters the stomach after a period of fasting, a drop in what initiates the conversion of pepsinogen to pepsin.
Example Output:
When food enters the stomach after a period of fasting, a drop in what initiates the conversion of pepsinogen to pepsin?