Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Q: Temperature and ph level are important in the activity of an enzyme.

A: Temperature and what other environmental factor are important in the activity of an enzyme?
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Q: A decline in blood flow to kidneys organs stimulates release of the enzyme renin, in turn stimulating the reabsorption of sodium and water.

A: A decline in blood flow to what organs stimulates release of the enzyme renin, in turn stimulating the reabsorption of sodium and water?
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Q: During the anaphase phase, sister chromatids separate and the centromeres divide.

A:
During which phase do sister chromatids separate and the centromeres divide?
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