Given scientific fact as input, generate the question from this fact such that it can be answered from the input.
Example: Earth rotates on its axis once times in one day.
Example solution: How many times does Earth rotate on its axis in one day?
Example explanation: The given output correctly poses a question based on the scientific fact given.

Problem: Muscarinic receptors can cause both depolarization or hyperpolarization depending on the subtype.
Solution: Muscarinic receptors can cause both depolarization or hyperpolarization depending on the what?