TASK DEFINITION: Given scientific fact as input, generate the question from this fact such that it can be answered from the input.
PROBLEM: Protons and neutrons are made of quarks, which are fundamental particles of matter.

SOLUTION: A fundamental particle of matter, protons and neutrons are made of these?

PROBLEM: Pleiotropic effects causes symptoms associated with sickle-cell disease.

SOLUTION: What causes symptoms associated with sickle-cell disease?

PROBLEM: Atoms of metals are good conductors of electricity because they give up electrons.

SOLUTION:
Why are atoms of metals good conductors of electricity?