Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Let me give you an example: Earth rotates on its axis once times in one day.
The answer to this example can be: How many times does Earth rotate on its axis in one day?
Here is why: The given output correctly poses a question based on the scientific fact given.

OK. solve this:
Most protein antigens require signals from helper t cells (th2) to proceed to make antibody.
Answer:
Most protein antigens require signals from helper t cells (th2) to proceed to make what?